<]/Prev 1597366>> Catharanthus roseus (The Madagaskar Periwinkle) plant is commercially valued for harbouring more than 130 bioactive terpenoid indole alkaloids (TIAs). (e-mail: dr.g.madhumitha@gmail.com) Catharanthus roseus-mediated zinc oxide nanoparticles against photocatalytic application of phenol red under UV@ 365 nm Aasaithambi Kalaiselvi1, Selvaraj Mohana Roopan2, Gunabalan Madhumitha2,*, 0000071032 00000 n (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.) 0000070953 00000 n Research article; Open Access; Published: 06 May 2016 Examining the transcriptional response of overexpressing anthranilate synthase in the hairy roots of an important medicinal plant Catharanthus roseus by RNA-seq. 0000142961 00000 n NIH The genus Catharanthus comprises 8 species, all originating from Madagascar except for the species Catharanthus pusillus, which is restricted to India and Sri Lanka (Flora of China Editorial Committee, 2015). Catharanthus roseus is a medicinal plant with various pharmacological properties. 0000091382 00000 n Periwinkle [Catharanthus roseus (L) G. Don] has become one of the very extensively investigated medicinal plants after the discovery of two powerful anti-cancer alkaloids, vinblastine and vincristine, in its leaves more than 50 years ago.These alkaloidal drugs are still in clinical use. Pharmacognosy of Catharanthus roseus (L.) G. Don (Sadabahar) Root and its Adulterants. It shows a number of therapeutic activities like antimicrobial, antidiabetic, anticancer, antiallergic, anti-inflammatory, cardioprotective activity etc. The genus Catharanthus is closely related to the genus Vinca and the species C. roseus was formerly known as Vinca rosea. 0000004838 00000 n Seeds of Catharanthus roseus ‘Pacifica Polka Dot’ were purchased from PanAmerican Seed and 900 seeds were sown at Taoyuan District Agricultural Research and Extension Station (TDARES). Abstract. It has attracted increasing attention due to it being shown to possess a range of phytochemicals with various biological activities such as antioxidant, antibacterial, antifungal, antidiabetic and anticancer properties. 0000139618 00000 n •In vitro biotechnological interventions prompted major genetic advancements. 0000071268 00000 n 279 0 obj <> endobj RESEARCH ARTICLE Open Access 1α, 25-dihydroxy Vitamin D3 containing fractions of Catharanthus roseus leaf aqueous extract inhibit preadipocyte differentiation and induce lipolysis in 3T3-L1 cells Anuj Kumar Borah1, Archana Singh1, Rafika Yasmin1, Robin Doley1, Venkata Satish Kumar Mattaparthi1 and Catharanthus roseus Linn (Apocynaceae), is a traditional medicinal plant used to control diabetes, in various regions of the world. 0000076916 00000 n The methanolic extracts also showed improvement in parameters like body weight and lipid profile as well as regeneration of -cells of pancreas in diabetic rats. hޤTkPTu?��܅x(���`fݽ�^"^� �����jX�4+4a߻�(�,�¬��TJ4�IY�"�,�/~�)'�)?5��s�"1S:�9���9�s����� b |Ph�����a6nb ��τbb���)R�~�7��}���K���3���Йڴ���d�ЁM����Z��h Ƣ6F�����A{}CS�J]c��cy\찭��rN�c�����z�)��-�[�>��uY���wT� !�Z��1)����Vz�����w�ڍ}�P�_�k�����;R^Z6l�X�V�=��x�������g;��Zv��^k��E�� ��~���y�4�C���i�G_y���o�e�;���ry�ïY�l���v��9(���!%�ѪU�"D?��eqym,g�h�ߠo�#. 0000070639 00000 n (e-mail: dr.g.madhumitha@gmail.com) Catharanthus roseus-mediated zinc oxide nanoparticles against photocatalytic 0000070245 00000 n Catharanthus roseus is the sole commercial source of the monoterpenoid indole alkaloids (MIAs), vindoline and catharanthine, components of the commercially important anticancer dimers, vinblastine and vincristine. 0000135441 00000 n It is grown in gardens and parks worldwide and it has escaped from cultivation and naturalized near houses, in disturbed sites, and in natural habitats in seasonal dry and humid habitats. Being a reservoir for more than 200 alkaloids, it reserves a place for itself in the list of important medicinal plants. 0000071346 00000 n 0000000016 00000 n Catharanthus roseus belonging to family Apocynaceae is a plant with high medicinal importance and wide occurrence all over the world. Cell line screening of Catharanthus roseus for high yield production of ajmalicine was conducted through subculturing of callus that induced from tetraploid plant leaves. 1, pp. 0000072215 00000 n A double-flowered mutant was identified from the ‘Pacifica Polka Dot’ population. 0000082023 00000 n It is popularly known as Madagascar periwinkle. Extraction yield (µg per g dry of plant material) of catharanthine and vindoline from Catharanthus roseus with the different solvents. 0000070009 00000 n Catharanthus roseus belonging to family Apocynaceae is a plant with high medicinal importance and wide occurrence all over the world. 0000143730 00000 n  |  0000143872 00000 n 0000141471 00000 n 1, pp. It has attracted increasing attention due to it being shown to possess a range of phytochemicals with various biological activities such as antioxidant, antibacterial, antifungal, antidiabetic and anticancer properties. The intricate networks of TIAs biosynthesis is regulated by all kinds of molecules such as plant signaling molecules (jasmonate acid, ethylene and nitric oxide), plant growth regulators, prenylated proteins and transcription factors. At pH 5.0, 1.7 mg of alkaloid/g dry weight was produced. 0000080814 00000 n Isolation, purification and maintenance of the endophytic fungus producing vinblastine and vincristine. NLM 0000070560 00000 n 0000072537 00000 n Benyammi R, Paris C, Khelifi-Slaoui M, Zaoui D, Belabbassi O, Bakiri N, Meriem Aci M, Harfi B, Malik S, Makhzoum A, Desobry S, Khelifi L. Pharm Biol. 0000140778 00000 n 398 0 obj <>stream A plastid‐localized bona fide geranylgeranyl diphosphate synthase plays a necessary role in monoterpene indole alkaloid biosynthesis in Catharanthus roseus Sarma Rajeev Kumar Molecular Plant Biology and Biotechnology Lab, CSIR‐Central Institute of Medicinal and Aromatic Plants, Research … The Madagascar periwinkle (Catharanthus roseus in the family Apocynaceae) is an important medicinal plant and is the source of several widely marketed chemotherapeutic drugs. 0000003953 00000 n Identification of a low vindoline accumulating cultivar of Catharanthus roseus (L.) G. Don by alkaloid and enzymatic profiling. Epub 2019 Jul 30. International Journal of Crude Drug Research: Vol. is a well known medicinal plant. 0000140109 00000 n 0000005022 00000 n (1988). ATP content increased in the leaves of C. roseus under UVB radiation. Clipboard, Search History, and several other advanced features are temporarily unavailable. Expression of tabersonine 16-hydroxylase and 16-hydroxytabersonine-O-methyltransferase in Catharanthus roseus hairy roots. 0000073467 00000 n 0000072298 00000 n 0000070324 00000 n V, Issue 2 / May 2017 1238 INTRODUCTION Catharanthus roseus is an evergreen ever blooming herb which has its origin in central Madagascar island. 0000143130 00000 n The substrate was applied to image distribution of the metabolites in very fragile specimens such as the petal of Catharanthus roseus. USA.gov. for Genome Research and Biocomputing, Oregon State University, Corvallis, OR, USA. Global warming contributes to higher temperatures and reduces rainfall for most areas worldwide. 0000004198 00000 n 0000070166 00000 n 0000142143 00000 n HHS Various types of metal NPs, like iron oxide, silver nitrate, copper oxide and zinc oxide have gained the attention of severa… Catharanthus roseus(L.) G. Don. 0000070875 00000 n Secondary metabolites are present in its leaves (e.g., vindoline, vinblastine, catharanthine, and vincristine) as well as basal stem and roots (e.g., ajmalicine, reserpine, serpentine, horhammericine, tabersonine, leurosine, catharanthine, lochnerine, and vindoline). 2020 Oct 12;13(10):303. doi: 10.3390/ph13100303. 0 0000093706 00000 n Research Article Catharanthus roseus Combined with Ursolic Acid Attenuates Streptozotocin-Induced Diabetes through Insulin Secretion and Glycogen Storage Huda Mohammed Alkreathy 1 and Aftab Ahmad 2 1Department of Pharmacology, Faculty of Medicine, … 20.3.6 Catharanthus roseus (Apocynaceae) C. roseus (L.) G. Don (Apocynaceae), also known as Vinca rosea and originating from Madagascar, has now spread throughout Africa as a result of human activities. 0000082459 00000 n 0000070796 00000 n 0000071977 00000 n The medicinal plant, Catharanthus roseus (C. roseus), accumulates a wide range of terpenoid indole alkaloids (TIAs). 0000089124 00000 n International Journal of Crude Drug Research: Vol. COVID-19 is an emerging, rapidly evolving situation. 0000089069 00000 n 0000076142 00000 n Production and metabolic engineering of terpenoid indole alkaloids in cell cultures of the medicinal plant Catharanthus roseus (L.) G. Don (Madagascar periwinkle). Pharmacognosy of Catharanthus roseus (L.) G. Don (Sadabahar) Root and its Adulterants. Materials and Methods. 11, 10 DECEMBER 2016 1811 *For correspondence. 0000091658 00000 n The leaf juice or water decoction of Catharanthus roseus L. (Apocyanaceae) is used as a folk medicine for the treatment of diabetes all over the world. Screening of the phenolic compounds from seeds, stems, leaves and petals of Catharanthus roseus (L.) G. Don (cv. 0000069530 00000 n trailer It is also commonly grown for its ornamental values and, due to ease of infection and distinctiveness of symptoms, is often used as the host for studies on phytoplasmas, an important group of uncultivated … 0000081799 00000 n 0000071743 00000 n 0000082703 00000 n 0000080009 00000 n It produces several phyto-compounds many of which show anticancerous properties. 0000077583 00000 n The substrate was applied to image distribution of the metabolites in very fragile specimens such as the petal of Catharanthus roseus. 2020 Oct 26;25(21):4945. doi: 10.3390/molecules25214945. Ethylene (ET) and methyl-jasmonate (MeJA) were previously reported as effective elicitors for the production of various valuable secondary metabolites of C. roseus, while a few ET or MeJA induced transcriptomic research is yet reported on this species. Research Article Catharanthus roseus Combined with Ursolic Acid Attenuates Streptozotocin-Induced Diabetes through Insulin Secretion and Glycogen Storage Huda Mohammed Alkreathy 1 and Aftab Ahmad 2 1Department of Pharmacology, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia Abstract. RESEARCH ARTICLE Open Access Development of efficient catharanthus roseus regeneration and transformation system using agrobacterium tumefaciens and hypocotyls as explants Quan Wang†, Shihai Xing†, Qifang Pan, Fang Yuan, Jingya Zhao, Yuesheng Tian, Yu Chen, Guofeng Wang and Kexuan Tang* The C. roseus cell suspension culture A11 accumulates the terpenoid indole alkaloids strictosidine, ajmalicine and vindolinine. It is native and endemic to Madagascar, but grown elsewhere as an ornamental and medicinal plant, a source of the drugs vincristine and vinblastine, used to treat … All groups were given a single dose of Streptozotocin (STZ) at a dose of 50 mg/kg by intraperitoneal route for induction of diabetes, except the normal control group. 11, 10 DECEMBER 2016 1811 *For correspondence. RESEARCH ARTICLES CURRENT SCIENCE, VOL. Vinblastine and vincristine are two important anti-cancer drugs that are synthesized by the Terpenoid Indole Alkaloids (TIAs) pathway in periwinkle (Catharanthus roseus). Till date, arrays of reports are available on in vitro biotechnological improvements of C. roseus. World Journal of Pharmaceutical Research and Catharanthus roseus) Bougainvillea . 0000071900 00000 n View Catharanthus Roseus Research Papers on Academia.edu for free. No vindoline roseus cells suspended in production medium showed the presence of four Aspidosperma‐type alkaloids,,! 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